Characterization of Soluplus/ASC-DP Nanoparticles Encapsulated with Minoxidil for Skin Targeting

Soluplus (Sol) is an amphiphilic graft copolymer capable of forming self-assembled micelles and L-ascorbyl 2,6-dipalmitate (ASC-DP) aggregates spontaneously to form micelles. Micelles are used as drug carriers can nanoparticulate drugs that poorly soluble in water, such minoxidil. The study aimed prepare minoxidil-encapsulated nanoparticles using Sol/ASC-DP evaluate their potential for targeted skin application. or with minoxidil were prepared the hydration method, physical evaluations carried out, including assessments particle size zeta potential. Particle structure was evaluated by transmission electron microscopy (TEM) 1H-nuclear magnetic resonance spectra assess stability perform functional penetration tests. TEM images showed spherical micelle-like particles approximately 100 nm at a 9:1 ratio 80 incorporated 9:1:0.5 ratio. Changes also observed solid state, suggesting hydrophobic interaction between Sol ASC-DP. In addition, evaporated microparticles (Sol/ASC-DP/minoxidil = 9/1/0.5) improved permeability These results suggest stable new nanoparticle due interactions, which would improve